## Abstract Monocytic differentiation of HL60 cells induced by 1,25‐dihydroxyvitamin D~3~ (1,25 D~3~) has been recently shown (Exp Cell Res 258, 425, 2000) to be enhanced by an exposure to SB203580 or to SB202190, specific inhibitors of p38MAP kinase, with concomitant up‐regulation of the c‐jun N t
✦ LIBER ✦
Sphingosine kinase 1 is involved in dibutyryl cyclic AMP-induced granulocytic differentiation through the upregulation of extracellular signal-regulated kinase, but not p38 MAP kinase, in HL60 cells
✍ Scribed by Masahiro Koda; Takashi Murate; Shulin Wang; Kenji Ohguchi; Sayaka Sobue; Mika Ikeda; Keiko Tamiya-Koizumi; Yasuyuki Igarashi; Yoshinori Nozawa; Yoshiko Banno
- Book ID
- 116272884
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 589 KB
- Volume
- 1733
- Category
- Article
- ISSN
- 1388-1981
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The signaling mechanisms leading to phorbol ester myristate (PMA)-induced differentiation of HL-60 cells to the macrophagelike phenotype were investigated by using different protein kinase inhibitors. The protein kinase C inhibitor Ro 31-8220 specifically blocks PMA-induced differentiation, activati