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Sphingosine 1-Phosphate Stimulates Gi- and Rho-Mediated Vascular Endothelial Cell Spreading and Migration

✍ Scribed by Hirotaka Okamoto; Yutaka Yatomi; Tsukasa Ohmori; Kaneo Satoh; Yoshiro Matsumoto; Yukio Ozaki

Book ID: 117256802
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 103 KB
Volume: 99
Category: Article
ISSN: 0049-3848
DOI: 10.1016/s0049-3848(00)00251-6

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## Abstract Sphingosine 1‐phosphate (S1P) and vascular endothelial growth factor (VEGF) are two inflammatory mediators capable of promoting endothelial cell (EC) migration and angiogenesis. As VEGF inflammatory effect is mediated by the synthesis of endothelial platelet‐activating factor (PAF) whic