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Sphingosine-1-Phosphate Induces Gαi-Coupled, PI3K/ras-Dependent Smooth Muscle Cell Migration

✍ Scribed by William Tanski; Elisa Roztocil; Mark G. Davies

Book ID
115636752
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
459 KB
Volume
108
Category
Article
ISSN
0022-4804

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## Abstract Sphingosine 1‐phosphate (S1P) has been shown to regulate smooth muscle cell proliferation, migration, and vascular maturation. S1P increases the expression of several proteins including COX‐2 in vascular smooth muscle cells (VSMCs) and contributes to arteriosclerosis. However, the mecha