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Sphingosine-1-phosphate induces early response gene expression in C6 glioma cells

✍ Scribed by Bradley J. Segura; Weizhen Zhang; Liqun Xiao; Craig D. Logsdon; Michael W. Mulholland


Book ID
116753227
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
208 KB
Volume
133
Category
Article
ISSN
0169-328X

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Treatment of rat glioma C6 cells with the ␀-adrenergic agonist L-isoproterenol leads to a rise in cAMP level and a subsequent change in cell morphology from an epithelial to an astrocytic type of appearance. This morphological response is reverted by the addition of sphingosine-1-phosphate (S1P) wit