Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling
โ Scribed by Chalfant, C. E.
- Book ID
- 126701338
- Publisher
- The Company of Biologists Ltd
- Year
- 2005
- Tongue
- English
- Weight
- 381 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0021-9533
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๐ SIMILAR VOLUMES
A novel regioselective synthesis of D-erythro -sphingosine 1-phosphate and D-erythro -ceramide 1-phosphate is described. The synthesis is based upon (1) in situ oxidative phosphorylation of the primary hydroxyl group in N-Boc-D-erythro-sphingosine utilizing trimethyl phosphite and carbon tetrabromid
## Abstract Readily available Dโ__erythro__โazidosphingosine is transformed into 3โ__O__โsilylโprotected derivative 6. Reduction of the azido group afforded 3โ__O__โsilylโprotected sphingosine 7 which was either converted into __N__โFmocโprotected derivative 8 or via Nโacylation into ceramide deriv