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Sphingomyelin-Derived Lipids Differentially Regulate the Extracellular Signal-Regulated Kinase 2 (ERK-2) and c-Jun N-Terminal Kinase (JNK) Signal Cascades in Airway Smooth Muscle

✍ Scribed by Susan Pyne; Joanna Chapman; Leslie Steele; Nigel J. Pyne


Book ID
115132261
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
1011 KB
Volume
237
Category
Article
ISSN
1432-1327

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## Abstract Treatment with 1–4 Β΅M As~2~O~3~ slightly induced apoptosis in U‐937 human promonocitic leukemia cells. This effect was potentiated by co‐treatment with MEK/ERK (PD98059, U0126) and JNK (SP600125, AS601245) inhibitors, but not with p38 (SB203580, SB220025) inhibitors. However, no potenti