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Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy

✍ Scribed by Barcelo-Coblijn, G.; Martin, M. L.; de Almeida, R. F. M.; Noguera-Salva, M. A.; Marcilla-Etxenike, A.; Guardiola-Serrano, F.; Luth, A.; Kleuser, B.; Halver, J. E.; Escriba, P. V.

Book ID: 126724293
Publisher: National Academy of Sciences
Year: 2011
Tongue: English
Weight: 663 KB
Volume: 108
Category: Article
ISSN: 0027-8424
DOI: 10.1073/pnas.1115484108

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## Abstract Interferon‐β (IFN‐β) has been used as an antitumor drug against human glioma, melanoma and medulloblastoma since the 1980s. Recently, we developed a new gene therapy using the __IFN__‐β gene against malignant gliomas and then began clinical trials in 2000. Since stimulation of immune sy