Spherical Molecularly Imprinted Polymers (SMIPs) via a Novel Precipitation Polymerization in the Controlled Delivery of Sulfasalazine

✍ Scribed by F. Puoci; F. Iemma; R. Muzzalupo; U. G. Spizzirri; S. Trombino; R. Cassano; N. Picci

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 168 KB
• Volume: 4
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200300035

✦ Synopsis

Abstract

Summary: Spherical molecularly imprinted polymers (SMIPs) have been prepared via a novel precipitation polymerization using sulfasalazine (prodrug used in the diseases of the colon) as template. The sulfasalazine was incorporated into SMIPs and into a spherical non‐imprinted polymer (control), and then the release rate of the bioactive agent at different pH values was evaluated. Considerable differences in the release characteristics between imprinted and non‐imprinted polymers have been observed. This opens the possibility of the development of drug release systems capable of modulating the release of a specific molecule.

Photomicrography of spherical molecularly imprinted polymers (SMIPs).

imagePhotomicrography of spherical molecularly imprinted polymers (SMIPs).