Spherical crystal agglomeration of ibuprofen by the solvent-change technique in presence of methacrylic polymers

Particle design of tolbutamide in the pr

Particle design of tolbutamide in the presence of soluble polymer or surfactant by the spherical crystallization technique: Improvement of dissolution rate

✍ A. Sano; T. Kuriki; T. Handa; H. Takeuchi; Y. Kawashima 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 436 KB 👁 1 views

Poorly soluble crystals of tolbutamide were modified in the presence of a soluble polymer or surfactant by the spherical crystallization technique, the objective being to improve the dissolution rate and to transform platelet crystals into spherical agglomerates. An HCI solution was added to a tolbu