Spermidine mediates degradation of ornithine decarboxylase by a non-lysosomal, ubiquitin-independent mechanism

✍ Scribed by James R. Glass; Eugene W. Gerner

• Book ID: 102882665
• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 941 KB
• Volume: 130
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1041300119

✦ Synopsis

The mechanism of spermidine-induced ornithine decarboxylase (ODC, E.C. 4.1.1.17) inactivation was investigated using Chinese hamster ovary (CHO) cells, maintained in serum-free medium, which display a stabilization of ODC owing to the lack of accumulation of putrescine and spermidine (Glass and Gerner: Biochem.