Sperm cryopreservation before cancer chemotherapy helps in the emotional battle against cancer

Frequency of minisatellite repeat number

Frequency of minisatellite repeat number changes at the MS205 locus in human sperm before and after cancer chemotherapy

✍ Ningjia Zheng; Darren G. Monckton; Gene Wilson; Fredrick Hagemeister; Ranajit Ch 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 114 KB

To determine whether the measurement of repeat number mutations at a minisatellite locus could detect human germline mutations induced by chemotherapy, we performed a longitudinal study of the mutation frequencies in sperm from 10 patients treated for Hodgkin's disease. Polymerase chain reaction on