SPEED: single-point evaluation of the evolution dimension

✍ Scribed by Eriks Kupče; Ray Freeman

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 108 KB
• Volume: 45
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/mrc.2052

✦ Synopsis

Abstract

Two‐dimensional NMR spectroscopy can be speeded up by orders of magnitude by severely restricting the number of sampling operations in the evolution dimension–we demonstrate that just a single measurement may suffice. The frequencies evolving in the indirect dimension (t~1~) are deduced from the amplitudes of the signals acquired in the direct dimension (t~2~). Prior measurements of the one‐dimensional spectra are required. Results are presented for the two‐dimensional ^13^C‐HSQC spectrum of 2‐ethylindanone recorded at a single fixed setting of the evolution time, demonstrating a speed advantage of 120. The method can be extended to multidimensional spectra, with correspondingly greater gains in speed. Copyright © 2007 John Wiley & Sons, Ltd.