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Spectrum of Spontaneous Mutation at the APRT Locus of Chinese Hamster Ovary Cells: An Analysis at the DNA Sequence Level

✍ Scribed by Pieter J. De Jong, Andrew J. Grosovsky and Barry W. Glickman

Book ID
123635557
Publisher
National Academy of Sciences
Year
1988
Tongue
English
Weight
782 KB
Volume
85
Category
Article
ISSN
0027-8424

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## Abstract Gamma radiation–induced gene rearrangements at the Chinese hamster ovary cell locus coding for the purine salvage enzyme adenine phosphoribosyl transferase (APRT) consist of both simple deletions and more complex alterations that are presumably the result of multiple strand breaks. To c