Spectrum of Mutations in BRCA1 Gene in Hereditary Forms of Breast and Ovarian Cancer in Russian Families
โ Scribed by A. N. Loginova; N. I. Pospekhova; L. N. Lyubchenko; A. V. Budilov; V. M. Zakhar'ev; R. F. Gar'kavtseva; E. K. Ginter; A. V. Karpukhin
- Book ID
- 111572609
- Publisher
- Springer US
- Year
- 2003
- Tongue
- English
- Weight
- 272 KB
- Volume
- 136
- Category
- Article
- ISSN
- 0007-4888
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We have screened index cases from 25 Russian breast/ovarian cancer families for germ-line mutations in all coding exons of the BRCA1 and BRCA2 genes, using multiplex heteroduplex analysis. In addition we tested 22 patients with breast cancer diagnosed before age 40 without family history and 6 patie
BRCA1 is a tumour suppressor gene located on chromosome band 17q21. It is estimated that mutations in the BRCA1 gene account for approximately 45% of the breast cancer families and almost all of the breast/ovarian cancer families. We have used single strand conformation polymorphism analysis, direct