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Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats

✍ Scribed by In Kyoung Lim

Book ID: 114096257
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 895 KB
Volume: 123
Category: Article
ISSN: 0047-6374
DOI: 10.1016/s0047-6374(02)00087-8

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## Abstract To clarify the sequential changes in pRB and __p16__ during different stages of hepatocarcinogenesis such as fibrosis, cirrhosis, hepatocellular adenoma (HCA), and hepatocellular carcinoma (HCC), male Fischer 344 rats were singly injected with diethylnitrosamine (DEN), immediately follo