Spectroscopic increase in choline signal is a nonspecific marker for differentiation of infective/inflammatory from neoplastic lesions of the brain
✍ Scribed by Sudhakar K. Venkatesh; Rakesh K. Gupta; Lily Pal; Nuzhat Husain; Mazhar Husain
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Volume
- 14
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
Abstract
We report in vivo proton magnetic resonance (MR) spectroscopic findings in three benign infective/inflammatory lesions (one case each of tuberculoma, fungal granuloma, and xanthogranuloma), which showed high choline along with the presence of lipid/lactate, a feature characteristically described in neoplastic lesions. Histopathology of the lesions showed inflammatory cellular infiltrates with areas of necrosis/caseation. The spectroscopic‐visible increased choline resonance in these lesions is probably the result of cellularity. We conclude that increased choline, along with the presence of lipid/lactate is a nonspecific finding and may not be of much value in the differentiation of neoplastic from nonneoplastic infective/inflammatory intracranial mass lesions. J. Magn. Reson. Imaging 2001;14:8–15. © 2001 Wiley‐Liss, Inc.