𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Spectroscopic detection of β -sheet structure in nascent Aβ oligomers

✍ Scribed by Mingjuan Wang; Renee D. JiJi

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
466 KB
Volume
4
Category
Article
ISSN
1864-063X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Deep‐UV resonance Raman (UVRR) spectroscopy and circular dichroism (CD) were employed to study the secondary structure of Aβ(1–42) in fresh samples with increasing fractions of oligomeric peptide. A feature with a minimum at ∼217 nm appeared in CD spectra of samples containing oligomeric Aβ(1–42). UVRR spectra more closely resembled those of disordered proteins. The primary difference between UVRR spectra was the ratio of the 1236 cm^–1^ to 1260 cm^–1^ amide III peak intensities, which shifted in favor of the 1236 cm^–1^ band as the fraction of oligomeric peptide increased. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

📜 SIMILAR VOLUMES

A mixed β-turn and β-sheet structure for
A mixed β-turn and β-sheet structure for bovine tooth enamel amelogenin: Raman spectroscopic evidence
✍ Siding Zheng; Antony T. Tu; V. Renugopalakrishnan; E. Strawich; Melvin J. Glimch 📂 Article 📅 1987 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 316 KB

Amelogenins, a class of sparsely phosphorylated hydrophobic proteins characterized by a high concentration of Pro, Gln, Leu, and His have been implicated in the mineralization of tooth Recently a unique primary structure of bovine tooth enamel amelogenin was reported by Takagi et al.,3 characterized

Structural transitions involved in a nov
Structural transitions involved in a novel amyloid-like β-sheet assemblage of tripeptide derivatives
✍ S. Ganesh; R. Jayakumar 📂 Article 📅 2003 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 167 KB

## Abstract Self‐assembly of two tripeptide derivatives containing three nonpolar isoleucine moieties and polar oxyethylene groups are studied in methanol. Peptide __A__ [CH~3~(OCH~2~CH~2~)~3~OCH~2~CO(Ile)~3~OCH~3~] and peptide __B__ [CH~3~(OCH~2~CH~2~)~3~OCH~2~CO(Ile)~3~NH (CH~2~CH~2~O)~3~CH~3~] t

Stability of secondary structural elemen
Stability of secondary structural elements in a solvent-free environment. II: The β-pleated sheets
✍ Aiqun Li; Catherine Fenselau; Igor A. Kaltashov 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB 👁 1 views

The stability of single ␤-strands and multistrand ␤-pleated sheets as elements of secondary structure is examined in the absence of intermolecular interactions. Such experimental conditions (e.g., complete removal of solvent molecules and counterions) are achieved by placing the peptide ions in the