A new, general and regioselective method
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Shahriyar Taghavi-Moghadam; Wolfgang Pfleiderer
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Article
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1997
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Elsevier Science
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French
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A new synthetic method for the preparation of 2,6-disubstituted 4-aminopteridines is described. Treatment of 2-substituted 4,5,6-triaminopyrimidincs with a-kctoaldoximes in MeOH affords in a regioselective one-step reaction 2,6-disubstituted 4-aminopteridines in high yield.