Spectrophotometric Determination of Cimetidine through Charge-transfer Reaction with 1,5-Dichloroanthraquinone as a π-Electron Acceptor
✍ Scribed by Xiaoling WEI; Liangwei DU; Lisheng WANG; Chunliu WEI; Zhiliang JIANG
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 97 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0256-7660
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Cimetidine reacting with 1,5‐dichloroanthraquinone in acetone solution can produce a charge‐transfer complex that shows a strong absorption peak at 343 nm. The absorption value at 343 nm increased with cimetidine concentration in the range of 0.01–0.5 µg/mL, with regression coefficient of 0.9995 and detection limit of 0.006 µg/mL. This simple and sensitive method has been successfully applied to determine cimetidine in tablets and capsules, with average recovery of (98.47±0.92)% and (97.07±1.16)%, respectively. Furthermore, the mole ratio of the complex between cimetidine and 1,5‐dichloroanthraquinone is 2:1, and the mechanism of charge‐transfer reaction is explored.