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Spectral response for laser enhancement in hepatic regeneration for hepatectomized rats

✍ Scribed by O. Castro-e-Silva Jr.; S. Zucoloto; L.G. Marcassa; J. Marcassa; C. Kurachi; C.A.S. Melo; F.S. Ramalho; L.N.Z. Ramalho; V.S. Bagnato

Book ID: 102466680
Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 79 KB
Volume: 32
Category: Article
ISSN: 0196-8092
DOI: 10.1002/lsm.10141

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✦ Synopsis

Abstract

Background and Objectives

The low intensity laser therapy (LILT) has been widely used in all medical fields due to its therapeutic effects in reparative process, pain relief, and biostimulation. Even though there is a therapeutic window of wavelengths for clinical application, little has been done concerning the frequency spectrum response to biological effects. In this work, we investigate the dependence of different wavelengths irradiation in the enhancement of the tissue regeneration after partial hepatectomy in Wistar rats.

Study Design/Materials and Methods

The proliferating cell nuclear antigen (PCNA) labeling index and the respiratory control (oxygen consumption in extracted mitochondria) were the tests used to evaluate the liver regeneration after laser irradiation with different wavelengths.

Results and Conclusions

The results show a correlated spectral response that can be explained based on the combined effect of light penetration on biological tissues and the biomolecular excitation efficiency for each wavelength used. Lasers Surg. Med. 32:50–53,2003. © 2003 Wiley‐Liss, Inc.

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