𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Specificity of hepatitis b virus affinity for human hepatic tissue

✍ Scribed by Dr. Larry I. Lutwick; M. Brenda Hebert; Todd Sklamberg

Book ID
102906660
Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
560 KB
Volume
9
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Using radiolabeled purified hepatitis B surface anligen and human liver slices, the affinity of hepatitis B virus to its host organ was evaluated. Saturable adsorption of the ^l25^I‐HB~S~ Ag complex to liver was demonstrated over both time and complex concentration which could be blocked by excess unlabeled antigen. The specific binding was not found using hurnan pancreas, lung, or kidney tissue. Correspondingly, no specific binding could be found for murine liver but it could be deinonslrated with woodchuck liver. The woodchuck is a natural host for one of the newly described hepatitis B‐like viruses which is antigenically cross‐reactive with the B virus.

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