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Specificity of aza-peptide electrophile activity-based probes of caspases

✍ Scribed by Sexton, K B; Kato, D; Berger, A B; Fonovic, M; Verhelst, S H L; Bogyo, M


Book ID
110017367
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
174 KB
Volume
14
Category
Article
ISSN
1350-9047

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## Abstract Recent characterization of multiple classes of functionalized azapeptides as effective covalent inhibitors of cysteine proteases prompted us to investigate __O__‐acyl hydroxamates and their azapeptide analogues for use as activity‐based probes (ABPs). We report here a new class of azagl