Specificity of autoantibodies react with ω-conotoxin MVIIC-sensitive calcium channel in Lambert-Eaton myasthenic syndrome

✍ Scribed by Akihito Suenaga; Susumu Shirabe; Tatsufumi Nakamura; Masakatsu Motomura; Mitsuhiro Tsujihata; Hidenori Matsuo; Yasufumi Kataoka; Masami Niwa; Masao Itoh; Shigenobu Nagataki

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 250 KB
• Volume: 19
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/(sici)1097-4598(199609)19:9<1166::aid-mus13>3.0.co;2-t

✦ Synopsis

Lambert-Eaton myasthenic syndrome (LEMS) is a neurological disorder characterized by reduced presynaptic release of acetylcholine.' Antibodies measured with o-conotoxin GVIA (GVIA), a long-lasting N-type calcium channel blocker, have been detected in 44-90% of patients with LEMS and in 10-42% of patients with small cell lung carcinoma (SCLC) without LEMS, as well as in patients with other autoimmune disease^.^," ' Lennon et al.3 and Motomura et al.fi reported that sera from patients with LEMS reacted with the calcium channels to which wconotoxin MVIIC (MVIIC) binds. To confirm and extend the work of Lennon et al. and Motomura et al., we used MVIIC to assay the anti-voltage-gated calcium channel (VGCC) antibodies in sera from patients with LEMS and compared the results with the results for GVIA.