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Specificity of an HLA-DRB1*0401-restricted T cell response to type II collagen

✍ Scribed by Lars Fugger; Jonathan B. Rothbard; Grete Sonderstrup-McDevitt


Book ID
102823986
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
655 KB
Volume
26
Category
Article
ISSN
0014-2980

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The impact of glycosylation on HLA–DR1–r
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## Abstract ## Objective Type II collagen (CII) is a candidate autoantigen implicated in the pathogenesis of rheumatoid arthritis (RA). Posttranslational glycosylation of CII could alter intracellular antigen processing, leading to the development of autoimmune T cell responses. To address this po