๐”– Bobbio Scriptorium
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Specificity of acquired clonal chromosome abnormalities in new zealand black mice

โœ Scribed by Philip J. Fialkow; Jean I. Bryant; Jan M. Friedman

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
507 KB
Volume
21
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

Abstract

New Zealand Black (NZB) mice, an inbred strain characterized by immunological dysfunction and lymphoreticular malignancy, also develop populations of aneuploid spleen cells. In detailed cytogenetic analyses performed on 10 NZBs, the chromosomally abnormal cells were found to be clonally related within each mouse. Moreover, the karyotypic changes observed were highly nonโ€random, usually involving the 15 (10/10 mice), 2 (8/10 mice), 16 or 17 (9/10 mice), and sex (6/10 mice) chromosomes. These observations suggest an important relationship between chromosomal alterations and tumorigenesis in NZB mice and emphasize the role of chromosome 15 in murine abnormal lymphoreticular proliferations.

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