Specificity in the hydrolysis of N-acyl-L-phenylalanine 4-nitroanilides by chymotrypsin
✍ Scribed by H. -D. Jakubke; H. Däumer; A. Könnecke; P. Kuhl; J. Fischer
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 257 KB
- Volume
- 36
- Category
- Article
- ISSN
- 1420-682X
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📜 SIMILAR VOLUMES
Using 1 -chloro-l-[~~N]nitrosocyclohexane, we have prepared five L-[a-'SN]arnino acids. The stereoselective electophillic hydroxyamination of (S)-acylbornane-l0,2-suftams, followed by ZnO/H+ reduction, and alkaline cleavage of the chiral auxiliary, gave the amino acids in 97.2-99.5 % e.e. By starti
## Abstract No‐carrier‐added (n.c.a.) 2‐[^18^F]fluoromethyl‐l‐phenylalanine (2‐[^18^F]FMP) was found to be very sensitive to hydrolysis in aqueous solutions. In this paper, the defluorination reaction was studied in detail to elucidate its mechanism. Therefore, besides 2‐[^18^F]FMP and 4‐[^18^F]FMP