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Specificity in addition of a halomethyl group to a model for a pyridine nucleotide coenzyme

โœ Scribed by Anthony Lombardo; Donald C. Dittmer


Book ID
103481561
Publisher
Elsevier Science
Year
1971
Tongue
English
Weight
571 KB
Volume
1
Category
Article
ISSN
0045-2068

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This paper describes the ยฎrst total synthesis of toddaquinoline, an alkaloid from the root bark of Formosan Toddalia asiatica. Importantly, the synthesis has exposed a dichotomy in radical reactions mediated by tin and cobalt(I) that involve additions to pyridines. Our observations suggest that coba