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Specific tritiation onto C-2 and C-5 positions of histidine - containing peptide. Application to thyroliberin

✍ Scribed by H. Levine-Pinto; P. Pradelles; J. L. Morgat; P. Fromageot

Book ID: 102372753
Publisher: John Wiley and Sons
Year: 1980
Tongue: French
Weight: 483 KB
Volume: 17
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580170210

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✦ Synopsis

Abstract

Specific methods of tritium labelling onto C‐2 and (or) C‐5 positions of the imidazole ring were successfully applied to thyroliberin (TRF, L‐Glu‐L‐His‐L‐Pro‐NH~2~).

Diazocoupling by diazotized sulphanilic acid and iodination by iodine monochloride of the histidyl residue were chosen to prepare precursors and to quantify the distribution of tritium atoms which were introduced.

Catalytic hydrogenolysis in the presence of tritium gas of 5‐iodohistidine^2^ ‐ and 2(4‐sulfophenylazo)histidine^2^ ‐ derivatives allowed to label these positions with specific radioactivities of 30 Ci and 25 Ci/mmole respectively. For comparison thyroliberin tritiated by direct catalytic exchange is labelled essentially onto C‐2 with a specific radioactivity of 30 Ci/mmole.

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