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Specific Tissue Distribution of Megsin, a Novel Serpin, in the Glomerulus and Its Up-Regulation in IgA Nephropathy

โœ Scribed by Reiko Inagi; Toshio Miyata; Daisuke Suzuki; Masao Toyoda; Takehiko Wada; Yasuhiko Ueda; Yuko Izuhara; Hideto Sakai; Masaomi Nangaku; Kiyoshi Kurokawa


Book ID
115588566
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
496 KB
Volume
286
Category
Article
ISSN
0006-291X

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Enzyme specificity and tissue distributi
โœ Shoji Takakura; Hideaki Minoura; Yukinori Shimoshige; Kyoko Minoura; Ikuo Kawamu ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 146 KB

## Abstract The enzyme specificity and tissue distribution of zenarestat, an aldose reductase inhibitor, was investigated in diabetic rats. Zenarestat inhibited both rat sciatic nerve aldose reductase (AR) activity and recombinant human AR with IC~50~ values of 7.5 and 44 nM, respectively. However,