Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

Tissue-specific growth suppression and c

Tissue-specific growth suppression and chemosensitivity promotion in human hepatocellular carcinoma cells by retroviral-mediated transfer of the wild-type p53 gene

✍ G W Xu; Z T Sun; K Forrester; X W Wang; J Coursen; C C Harris 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 646 KB

HCC patients are generally resistant to chemotherapy, Selective expression of cytotoxic gene products in tuwhich, in some cases, may be the result of a loss of function mor cells is one of the goals of gene therapy for treating mutation in the p53 gene. cancer. We are developing such a strategy for