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Specific region of the c-myc promoter is responsive to electric and magnetic fields

✍ Scribed by Hana Lin; Reba Goodman; Ann Shirley-Henderson

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
716 KB
Volume
54
Category
Article
ISSN
0730-2312

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✦ Synopsis

The level of c-myc transcripts is increased in cells exposed to extremely low frequency (elf) electromagnetic (EM) fields at 60 Hz. The aim of the present experiments was to determine if regulatory regions upstream of the c-myc gene modulate the response to EM fields. DNA upstream of P I of both mouse and human c-rnyc genes was transfected into cells as CAT constructs. The presence of DNA 5' to the human or mouse myc genes results in increased expression of CAT following 20 min exposures of cells to 60 Hz elf EM fields. Specific portions of the human upstream DNA were deleted and introduced into cells. The region responsive to EM fields is located between -353 and -1,257 relative to the PI promoter.

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