Specific pH-Responsive Folate-Conjugate Microgels Designed for Antitumor Therapy
✍ Scribed by Leyre Pérez-Alvarez; Virginia Sáez-Martínez; Estíbaliz Hernaez; M. Herrero; Issa Katime
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 452 KB
- Volume
- 210
- Category
- Article
- ISSN
- 1022-1352
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✦ Synopsis
Abstract
Colloidal nanosized folate‐conjugated hydrogels for targeted chemotherapy were prepared via a versatile and efficient postsynthetic modification pathway starting from P(NPA__‐co‐__NIPAM). The modifications included the introduction of 4‐methylpyridine as pH‐sensitive pendant groups and the conjugation of folic acid to the microgel network. The microgels showed a specific swelling at pH < 6 (endosomes) as judged by DLS studies varying the external pH. The relative composition of the microgels shows a clear influence on the pH volume transition shifting. The potential of the microgels for anticancer drug release at pH = 5.0 was confirmed. Therefore, they are a promising targeting carrier for improved anticancer chemotherapy.
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