Specific Method for the Determination of Genomic DNA Methylation by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry
โ Scribed by Song, Liguo; James, Smitha R.; Kazim, Latif; Karpf, Adam R.
- Book ID
- 126899590
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 149 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0003-2700
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๐ SIMILAR VOLUMES
The behaviour of 5-methyl-2'-deoxycytidine (m 5 dCyd, claimed to be a potential marker for leukaemia) during the electrospray process was studied. In particular, considerations concerning the effect of solution chemistry (e.g. analyte concentration, pH, etc.) on electrospray ionization mass spectra
## Abstract Endogenous carcinogens arising from normal metabolism are known to cause modifications to DNA by reacting with bases to form adducts. Malondialdehyde is a well characterized endogenous carcinogen that forms an adduct with 2โฒโdeoxyguanosine. This adduct has been detected in rat and human