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Specific metaphase and interphase detection of the breakpoint region in 8q24 of burkitt lymphoma cells by triple-color fluorescence in situ hybridization

โœ Scribed by Thomas Ried; Christoph Lengauer; Thomas Cremer; Joop Wiegant; Anton K. Raap; Mels Van Der Ploeg; Peter Groitl; Martin Lipp

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
675 KB
Volume
4
Category
Article
ISSN
1045-2257

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โœฆ Synopsis

Triple fluorescence in situ hybridization with a plasmid DNA library from sorted human chromosomes 8 in combination with bacteriophage clones flanking the breakpoint in 8q24 of the Burkitt lymphoma cell line )I was used for the specific delineation of this breakpoint in individual tumor cells. With this approach, tumor-specific breakpoints in translocation chromosomes can be detected at all stages of the cell cycle with high specificity. Genes Chrorn Cancer 4: 69-74 (1992).

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