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Specific lysis by CD8+ T cells of Schwann cells expressing Mycobacterium leprae antigens

✍ Scribed by Ulrich Steinhoff; Stefan H. E. Kaufmann

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
638 KB
Volume
18
Category
Article
ISSN
0014-2980

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✦ Synopsis

Specific lysis by CD8' T cells of Schwann cells expressing Mycobacterium leprae antigens*

In vitro cultured murine Schwann cells which were devoid of class I and class I1 gene products of the major histocompatibility complex expressed class I, though not class 11, antigens after stimulation with recombinant interferon-y. Recombinant 1FN-ystimulated Schwann cells after priming with M. leprue were lysed by antigen-specific CD8' T lymphocytes in vitro. These findings suggest that specific lysis of M . lepraeinfected Schwann cells by CD8' CTL plays a role in leprosy.

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