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Specific lymphocyte transformation in murine malaria

✍ Scribed by J. Golenser; D. T. Spira; J. P. Verhave; J. H. E. Th. Meuwissen

Publisher
Springer-Verlag
Year
1976
Tongue
English
Weight
209 KB
Volume
50
Category
Article
ISSN
1432-1955

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✦ Synopsis

Lymphoblast transformation tests were performed on convalescent rats and mice, after infection with Plasmodium berghei had been reduced to latency. Spleen cells from immune animals reacted in vitro to specific plasmodial antigen and not to control antigen produced from non infected RBC. The response in vitro was dependent on the concentration of the antigen and the time of exposure to it. A correlation was observed between the parasitaemia of the convalescent animal during its acute infection and the reaction in vitro: the higher the parasitaemia the higher the in vitro simulation.

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