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Specific-locus mutations induced with hepatocarcinogens in a subcutaneous granulation tissue in rats

โœ Scribed by P. Maier; H.P. Schawalder; G. Zbinden

Book ID
113250846
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
68 KB
Volume
130
Category
Article
ISSN
0165-1161

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In a previous study, we found that treating transgenic Big Blue rats with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene (N-OH-AAF) produced the same major DNA adduct in the target liver and the nontarget spleen lymphocytes and bone marrow cells, induced lacI mutants in the liver, and induced