Specific interactions in high concentration antibody solutions resulting in high viscosity
โ Scribed by Sandeep Yadav; Jun Liu; Steven J. Shire; Devendra S. Kalonia
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 258 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
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The purpose of this work was to understand the viscosity behavior of highconcentration monoclonal antibody (mAb) solutions in a wide range of solution conditions and generate guidelines helpful to formulate products with manageable viscosity. The zeta potential and effective isoelectric point (pI) w
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## Abstract Viscosity and density of homogeneous oneโphase solutions (1 wt %) of polyethylenes with narrow molecular weight distributions (__M__~__w__~ = 2150, 15,520, 108,000, and 420,000) in __n__โpentane were determined at 398, 413, and 428 K over a pressure range from 20 to 60 MPa. Measurements