Specific Inhibitors of Vacuolar H+-ATPase Trigger Apoptotic Cell Death of Osteoclasts
โ Scribed by Nobuo Okahashi; Ichiro Nakamura; Eijiro Jimi; Masanori Koide; Tatsuo Suda; Tatsuji Nishihara
- Book ID
- 111486124
- Publisher
- American Society for Bone and Mineral Research
- Year
- 1997
- Tongue
- English
- Weight
- 627 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0884-0431
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Although bisphosphonates have been shown to be potent inhibitors of osteoclastโmediated bone resorption in vivo and in vitro and are used as therapeutic agents in hyperโresorptive bone diseases such as Paget disease or hypercalcemia of malignancy, their exact biochemical target(s) and m
We investigated effects of bafilomycin A,, a specific inhibitor of vacuolar-type H'-ATPase (V-ATPase), and its analogues on proliferation of various cultured cells. The proliferation of the various cell lines was suppressed by adding bafilomycin A, to the culture medium. This inhibitory effect appea
## Abstract We report the effects of specific and potent inhibitors of vacularโtype H^+^โATPase and lysosomal cysteine proteinases, cathepsins, on the ultrastructure, expression of these enzymes, and resorptive functions of cultured osteoclasts. Osteoclasts were formed by coโculture of marrow cells
## Abstract Bafilomycin A1, a specific inhibitor of VโATPases, is a potent inhibitor of bone resorption, but the underlying mechanisms of its action remain unclear. In this study, we investigated the effect of Bafilomycin A1 on endocytosis and apoptosis in RAW cells and RAW cellโderived osteoclasts