## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Specific Inhibitors of the Breast Cancer Resistance Protein (BCRP)
β Scribed by Anne Pick; Werner Klinkhammer; Michael Wiese
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 423 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1860-7179
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Drug resistance plays an important role in chemotherapy failure in breast cancer. We studied the expression of MDR1, MRP, LRP, DNA topoisomerases, p53 and Ki-67 in different groups of breast cancer patients in relation to chemotherapy. Tissues from 6 normal breasts and 20 primary operable, 40 locall
## Abstract ## BACKGROUND Breast cancer resistance protein (BCRP) functions as a drug efflux transporter that mediates drug resistance. Topoisomerase I inhibitors, including 7βethylβ10βhydroxycamptothecin (SNβ38), are substrates effluxed by BCRP. However, it remains unclear whether the overexpress