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Specific inhibition of p38 mitogen-activated protein kinase with FR167653 attenuates vascular proliferation in monocrotaline-induced pulmonary hypertension in rats

✍ Scribed by Jun Lu; Hideto Shimpo; Akira Shimamoto; Albert J. Chong; Craig R. Hampton; Denise J. Spring; Masaki Yada; Motoshi Takao; Koji Onoda; Isao Yada; Timothy H. Pohlman; Edward D. Verrier

Book ID: 113759562
Publisher: CTSNet
Year: 2004
Tongue: English
Weight: 533 KB
Volume: 128
Category: Article
ISSN: 1097-685X
DOI: 10.1016/j.jtcvs.2004.03.003

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Prevention of the onset and progression

Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653

✍ Masataka Nishikawa; Akira Myoui; Tetsuya Tomita; Koichiro Takahi; Akihide Nampei 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 488 KB 👁 2 views

## Abstract ## Objective FR167653 is a potent inhibitor of p38 mitogen‐activated protein kinase (MAPK) and inhibits tumor necrosis factor α (TNFα) and interleukin‐1β (IL‐1β) production in inflammatory cells. In this study we investigated the effect of FR167653 on collagen‐induced arthritis (CIA).