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Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector

✍ Scribed by van de Wetering, Marc; Oving, Irma; Muncan, Vanesa; Pon Fong, Menno Tjon; Brantjes, Helen; van Leenen, Dik; Holstege, Frank C.P.; Brummelkamp, Thijn R.; Agami, Reuven; Clevers, Hans

Book ID: 110033644
Publisher: Nature Publishing Group
Year: 2003
Tongue: English
Weight: 278 KB
Volume: 4
Category: Article
ISSN: 1469-221X
DOI: 10.1038/sj.embor.embor865

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## Abstract Silencing of a specific mRNA using double stranded RNA oligonucleotides represents one of the newest technologies for suppressing a specific gene product. Small interfering RNA (siRNA) are 21 nucleotides long, double stranded RNA fragments that are identical in sequence to the target mR