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Specific increase in enzymatic activity of adenosine deaminase 1 in rheumatoid synovial fibroblasts

✍ Scribed by Yuji Nakamachi; Masahiro Koshiba; Takashi Nakazawa; Saori Hatachi; Ryuichi Saura; Masahiro Kurosaka; Hideaki Kusaka; Shunichi Kumagai

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 98 KB
Volume: 48
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.10956

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## Abstract ## Objective Membrane‐associated prostaglandin E synthase (mPGES) is a recently identified terminal enzyme of the arachidonic acid cascade, which converts PGH~2~ to PGE~2~ in rheumatoid arthritis synovial fibroblasts (RASFs). This study was undertaken to investigate factors regulating