✦ LIBER ✦
Specific in vitro labeling of cells with a fluorine-19 probe encapsulated in antibody - targeted liposomes: A F-19 NMR spectroscopy study
✍ Scribed by Jean Vion-Dury; Patrick Machy; Sylviane Confort-Gouny; Lee Leserman; Patrick J. Cozzone
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 403 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
Liposomes containing dexamethasone phosphate (DMp) were covalently coupled to protein A and then incubated with mu‐rine L929 fibroblast and RDM4 thymoma cells in the presence of monoclonal antibodies specific for the major histocompatibility complex. The detection of the specific F‐19 labeling of cells is rapid (minutes). Such a strategy might be useful to study the kinetics of internalization processes of bound lipo‐somes on cultured living cells.