Specific immune responses after booster immunization with tetanus toxoid in man: Study of kinetics, family segregation, and linkage toHLAof in vitro lymphocyte proliferative responses and serum-antibody responses
✍ Scribed by J. J. Ballet; C. Rabian-Herzog; M. Lathrop; J. -F. Bourge; M. Agrapart; J. Drouet; J. -M. Lalouel; J. Dausset
- Publisher
- Springer-Verlag
- Year
- 1983
- Tongue
- English
- Weight
- 974 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0093-7711
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✦ Synopsis
Kinetics and family transmission of antigen-specific in vitro cellmediated responses were investigated in 68, and serum-antibody responses to tetanus toxoid (TT) in 73 individuals from a total of 12 families. Proliferative responses to highly purified TT monomer were studied in 6-to 7-day lymphocyte cultures. The effect of booster immunization was detectable 7 (DT) and 30 (D30), but not 120 days (D120) later. The sex of donors was not found to have any influence. A significant influence of the time interval since the last immunization was found for the responses at D 7 and D30. Data were correspondingly adjusted for segregation and linkage analyses. Several transmission hypotheses for the data obtained at D 7 and D30 were evaluated by likelihood ratio tests. Observations at D30 were compatible with the hypothesis of a control by a dominant genetic determinant for high responses closely linked to the major histocompatibility complex region. No such evidence could be found for D 7. After booster immunization, mean antibody levels determined on D7, D30 (peak of response), and D 120 were found to be higher than those prior to immunization (Do). The sex of the donors was found to have no influence on antibody responses. The time interval since the last immunization and the age of donors both had a slight influence, and data were correspondingly adjusted for segregation and linkage analyses, which showed no evidence of genetic control of the antibody responses or of linkage to HLA.