Specific hybridization arrest of dihydrofolate reductase mRNA in vitro using anti-sense RNA or anti-sense oligonucleotides

Effects of anti-sense oligonucleotides d

Effects of anti-sense oligonucleotides directed toward dihydrofolate reductase RNA in mammalian cultured cells

✍ Mercè Rodríguez; Véronique Noé; Cristina Alemany; Angela Miralles; Valentina Bem 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 149 KB

The effect of incubations with anti-sense phosphorothioate oligonucleotides directed toward sequences of dihydrofolate reductase (DHFR) RNA has been tested on Chinese hamster ovary cells. The selected targets were the 5'-untranslated region, the translational start, the splice sites and branch point