Specific gas chromatographic determination of phenothiazines and barbiturate tranquillizers with the nitrogen flame ionizations detector

✍ Scribed by M. Riedmann

• Publisher: Elsevier Science
• Year: 1974
• Tongue: English
• Weight: 322 KB
• Volume: 92
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(00)97188-7

✦ Synopsis

The advantages of the use of the nitrogen flame ionization detector (N-FID), particularly for the analysis of phenothiazines, barbiturate tranquillizers and other nitrogen-containing organic drugs, are discussed and compared with the electron capture detector and flame ionization detector.

The sensitivity, selectivity, and the response characteristics of the N-FID to organic nitrogen are independent of the chemical structure of a particular drug, so that the method requires biological sample volumes of only about 100 ~1. simplifies extraction procedures and increases the detection specificity and accuracy of the analytical data.