Specific effect of zinc ions on DNA polymerase activity of avian myeloblastosis virus

✍ Scribed by Prabhudas R. Palan; Maxwell L. Eidinoff

• Book ID: 104678413
• Publisher: Springer
• Year: 1978
• Tongue: English
• Weight: 195 KB
• Volume: 21
• Category: Article
• ISSN: 0300-8177
• DOI: 10.1007/bf00240277

✦ Synopsis

The effect of selected cations on DNA synthesis by DNA-polymerase of avian myeloblastosis virus (AMV) was studied. Zinc ions at low concentration (0.2mM) in the assay system enhanced the activity about 2 x fold and at higher concentration (2.0 mM) inhibited the activity completely. In contrast, addition of lithium and potassium salts produced inhibitory effects in this ionic concentration range. Replacement of K+ ion had an inhibitory effect on the activity.