Specific DNA methylation sites in the vicinity of the chicken β-globin genes
✍ Scribed by MCGHEE, JAMES D.; GINDER, GORDON D.
- Book ID
- 109715689
- Publisher
- Nature Publishing Group
- Year
- 1979
- Tongue
- English
- Weight
- 254 KB
- Volume
- 280
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/280419a0
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📜 SIMILAR VOLUMES
An investigation of the correlation between the y->p-globin switch and DNA methylation was carried out. The restriction patterns obtained with methylation-sensitive and -insensitive enzymes indicated hypomethylation in the promoter region of the r-globin genes in fetal liver DNA but high methylation
## Abstract We have studied the effect of site‐specific cytosine methylation on the binding of nuclear proteins to the γ‐globin promoter region from −71 to −34. This sequence was recently shown to contain a stage selector element responsible for increased transcription from the γ compared to the β