Specific cleavage of histidine-containing peptides by copper (II)
β Scribed by ALLEN, GEOFFREY ;CAMPBELL, RICHARD O.
- Book ID
- 115099883
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 960 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0367-8377
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## Abstract We review recent developments in the studies of Cu(II) complexes with histidineβcontaining peptides in solution by NMR. An overview of the theoretical background of the effects of the paramagnetic metal on the NMR properties (relaxation and shift) of nearby nuclei is given. Particular a
## Abstract Several reports have highlighted the interest of replacing Gly, a frequent amino acid within bioactive peptides, by azaGly (Agly) to improve their stability, activity or for the design of prodrugs. Because metal catalysis is increasingly used for tailoring peptide molecules, we have stu